The strong anion exchange ligand of Capto Q XP, comprising a quaternary amine group, is well established in large-scale purifications.
BioProcess resin supported for industrial applications. Hydrophilic properties of base matrix prevent non-specific binding. Higher throughput for improved productivity and process economy. The program consists of Coromant Capto sizes C6, C5 and cylindrical shanks in diameter 20, 25 and 32 mm (0.79, 0.94 and 1.26 inch) with a reach of 35 times the cutting diameter, DC. Capto Q XP extends the well-established Capto platform to include resin for intermediate purification and polishing of large biomolecules. Flexible process design due to a large operational window of flow velocities and bed heights. well as purification of HSA fusion proteins, blood coagulation factors, enzymes. The cutters are designed for reach and at the same time efficient when machining close to chucks in multi-task machines. Capto MMC combines agarose base matrix developments with innovative ligand chemistry, giving a different selectivity compared to traditional ion exchangers. GE Healthcare has released Capto Blue affinity chromatography medium. It is suitable for the removal or purification of proteins at both laboratory and process scales.ĭepending on the target molecule, the ligand functionality of Capto Blue may be modified through the use of appropriate buffer salts and buffer conductivity to increase selectivity for desired targets.Ĭapto Blue medium’s chemical stability also ensures tolerance for sodium hydroxide, enabling repeated cleaning-in-place (CIP) procedures to remove tightly bound impurities and maintain capacity. Capto MMC is based on rigid, high-flow agarose that allows high flow, which is an important factor for raising productivity in large-scale operations.
The chromatography medium has multiple purposes that include the capture of human serum albumin (HSA), as well as purification of HSA fusion proteins, blood coagulation factors, enzymes, and recombinant proteins at laboratory and process scales. GE Healthcare has released Capto Blue affinity chromatography medium, promoting the new product as being more chemically stable with a more rigid agarose base matrix than its predecessor, allowing for faster flow rates and larger sample volumes, which leads to higher throughput and improved process economy. Viral clearance using Capto adhere was tested with two representative model viruses, Minute Virus of Mice (MVM) and Murine Leukemia Virus (MuLV).
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